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Nanoknife doubles the survival rate of advanced stage pancreatic cancer patients

Currently, the complication rate of radiofrequency ablation for the treatment of pancreatic cancers is about 28％-40％, and the mortality is 7.5%. Now, the three problems of pancreatic cancer physical ablation therapy are uncomprehensive ablation, blood vessel damaged and intestine wall and pancreatic duct injured, which can be greatly solved by nanoknife with the advantages of killing cancer cells by damage cancer cell construction by electrical current, without any injure on important organizations such as blood vessels, intestinal canal and nerve. Referring to the study from American Surgical Association, most of the pancreatic cancer patients can have double survival rate.

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How does Nanoknife work?
  • Release high voltage pulses from electrode probes
  • break through tumor cells, resulting in multiple permanent nano-meter irreversible electroporation
  • damage membrane of tumor cells
  • accelerate death of cancer cells
  • phagocytes of human body eliminate the dead tissues
Nanoknife is suit to treat what kind of tumors?

Nanoknife is applied to pancreatic cancer, liver cancer, lung cancer, kidney cancer, prostate cancer and other solid tumors, which possesses unique advantages for tumors closing to liver gate area, gall bladder, bile duct, pancreas and ureter.

Advantages of Nanoknife
1
Short ablation duration

Each pair of probe releases 90 times of ultra-short pulse and each group of ablation takes less than 1 minute.Even if the solid tumor reaches 3cm in diameter, the whole ablation duration would be less than 5 minutes.

2
Safe and controllable treatment process

Guided by CT or MRI and other imaging devices, doctor can have a real-time monitoring on probe position, ablation process of target area and final size of the ablation zone, observing changes in the surrounding tissue ablation zone, ensuring effect and security which contribute to a rapid postoperative recovery.

3
Distinct border of ablation area

Regardless of location, size and form of the tumor, complete ablation can be got through Nanoknife. After ablation, there is clear boundary between the ablated and unabated areas, which means no residual lesion and therefore lower the risk of recurrence.

4
Reserve vein, nerve and other normal tissues

After Nanoknife treatment, vessel, bile duct, nerves, ureters and other structures within ablation zone can be preserved without any irreversible damage. For Nanoknife in hepatic zone, important hepatic tissues such as hepatic artery, hepatic vein, portal, intrahepatic bile duct can be well protected after the treatment.

5
Rapid recovery of ablation zone

Nanoknife technology has an induction effect on death of cancer cells, and then phagocytes of human body will eliminate the dead tissues, promoting regeneration and repair of normal tissues.

6
Adaptable to More complicated condition

Conventional ablation is forbidden for tumors located near large blood vessels, bile duct, pancreatic duct, hepatic portal vein, etc. However, Nanoknife has none such contraindication, which avoids injure on pipeline and nerves.

Nanoknife for pancreatic cancer was performed successfully in Modern Cancer Hospital Guangzhou

Nanoknife for pancreatic cancer was performed successfully in Modern Cancer Hospital Guangzhou. Li Xingde (alias), from Indonesia, was diagnosed with pancreatic cancer stage 3, tumor size of 4.5 × 4cm. Due to rather special anatomical position of the pancreas, pancreatic surgery is of high risk and no radical resection. Moreover, chemotherapy and radiation has limited treatment effect on pancreatic cancer. In this case, advantages of Nanoknife perfectly make up the short boards of pancreatic cancer treatment. Nanoknife is to destroy cancer cell membrane structure by using of electric current, leading to cell death, without damaging surrounding tissues such as blood vessels, bowel, and nerves. After a joint consultation over his case, MDT of MCHG decides to adopt the most advanced Nanoknife for him.

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Nanoknife therapy is suitable for these patients:
1. Early, middle and advanced stage cancer patients;
2. Patients unsuitable or unwilling to undergo surgery or chemotherapy;
3. Relapsing cancer patients who cannot tolerate surgery again;
4. Conventional treatments performed patients who show limited effects;
5. Tolerability and adverse reactions showed patients for chemotherapy.
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Who is forbidden for nanoknife?
1. Patients with existence of implanted pacemaker or defibrillator within ablation region
2. Patients with implanted electronic equipment and metal parts near the ablation region
3. Lesion of eyes, including the eyelids
4. Patients with a medical history of seizures or cardiac arrhythmias
5. Patients have myocardial infarction recently.
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